Dextromethorphan-d3 (CRM)

3-methoxy-17-(methyl-d3)-, (9a,13a,14a)-morphinan
\n Dextromethorphan-d3 (CRM) contains three deuterium atoms at the 17-methyl group. It is intended for use as an internal standard for the quantification of dextromethorphan by GC- or LC-mass spectrometry. Dextromethorphan (DXM) (Item Nos. ISO60141 | 13950) is a dextratrorotatory morphinan with structural similarity to levorphanol, codeine, and morphine. Because of its strong antitussive effects, DXM is widely used as a cough suppressant.{21979} However, it does not provoke opioid activity as is characteristic of several other morphine derivatives. DXM binds to and inhibits NMDA (IC50 = 0.55 μM) and nicotinic receptors (IC50s = 0.7-3.9 μM) and blocks receptor-gated and voltage-gated calcium channels (IC50 = 60 μM) and voltage-gated sodium channels (IC50 = 78 μM).{21979,21978,21981} DXM has been used in multimodal analgesic therapies for acute and neuropathic pain.{21979,21980} Cayman Chemical products containing Certified Reference Material (CRM) in the name are highly qualified materials manufactured and tested to meet ISO/IEC 17025 and ISO Guide 34 international guidelines for reference materials. These materials are tested using validated analytical methods on qualified instrumentation to ensure traceability to SI units of measure. Cayman’s CRMs are tested for Homogeneity and Stability and are provided with a certificate stating the CRM property value(s) along with the combined uncertainty of the property value(s). These materials are intended for quantitative applications where quantitative accuracy and uncertainty are critical. Cayman Chemical is committed to providing quality products to its customers as evidenced by its accreditation to the ISO/IEC 17025 and ISO Guide 34 standards. All traceable CRMs may be distinguished by their CofAs and can be downloaded below using the batch number located on the product label. For a representative CofA please contact our technical support.